In the larva fish, scientists saw the formation of hematopoietic cells. Since the mechanism is identical to what happens in the human body, you can now understand how to run it in humans.
More and more processes in living organisms, biologists can now see with our eyes, and thus directly to understand their mechanisms. Professor of Biology David Trever (David Traver) and a team of researchers from the University of California at San Diego have seen in real time, as formed in the embryo hematopoietic stem cells, which then give rise to all types of blood cells. Scientists have found that the precursors of blood cells arise from endothelial - cells of the inner wall of the vessel.
Make the invisible visible to scientists for the umpteenth time already helped a little fish zebrafish (Danio rerio) - a favorite object of geneticists and embryologists. She has a transparent larva, so that all processes of development at hand. But we need to provide the desired cells with fluorescent labels, which use the technique of transgenic animals: associate gene fluorescent protein gene to protein, you want to see. Well then living zebrafish larvae are considering using a fluorescent microscope.
Due to the fact that proteins are synthesized in the cells of the vascular wall, painted with a red fluorescent label, a protein specific to blood cells, stained green label, the researchers saw and took off for the camera, as hematopoietic cells originate from endothelial cells in the dorsal aorta - the first blood vessel of the embryo .
The basic processes of development in all vertebrates are very similar, what proof - the resemblance of embryos. Therefore there is no doubt that human hematopoietic cells arise in the same way as in fish.
16 February 2010
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