What is the real cure for depression

Is Esketamine Safe At All?

Even with short-term therapy with the new agent, side effects such as drowsiness, increased blood pressure and even psychotic episodes can occur. No information at all was presented on the safety of Spravato with long-term use (after approx. 15 months).

In addition, six patients died during the clinical studies, three of them by suicide (2). In comparison, there was no death in the control group, so that an increased risk of suicide is apparently one of the side effects of the drug. Janssen and the FDA said the deaths were unrelated to esketamine.

The approval of esketamine is already in sight in Europe

Esketamine is obtained from the anesthetic (narcotic / narcotic) ketamine, which was discovered in the early 1960s and is also abused as a drug. Ketamine has been used for some time in therapy-resistant patients for depression in the USA and also in Europe. It is used "off label" by clinicians, which means it is not approved for use in depression.

Ketamine has not yet been officially approved for depression because it is classified as not very profitable by the pharmaceutical companies. It is different with Spravato. This is because the active ingredient esketamine was patented as a new drug in the form of a nasal spray and now costs more than 4,700 US dollars per person in the first month of treatment.

According to Thomas Messer, psychiatrist and chief physician at the Danuvius Klinik (specialist clinic for psychiatry, psychotherapy and psychosomatic medicine) in Pfaffenhofen, approval for Spravato could be granted in Europe as early as 2020 (3).

Naturopathy instead of antidepressants?

In the case of depression, however, there are numerous naturopathic options available that are unfortunately almost never addressed or recommended by the treating physicians, although they are free of side effects and often achieve very good results. Therefore, before you get a prescription for questionable medication, you could first choose the holistic route. You can find further information on natural therapy for depression here:

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  • (1) Herrera-Perez D et al, Meta-Research: A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals, elife, June 2016
  • (2) Emmarie Huetteman, FDA overlooked red flags in drugmaker's testing of new depression medicine, Medical Xpress, June 2019
  • (3) Drugs for Depression, Heise, April 2019

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This information is passed to the best of my knowledge and belief. They are intended exclusively for those interested and for further training and are in no way to be understood as diagnostic or therapeutic instructions. We do not assume any liability for damages of any kind that arise directly or indirectly from the use of the information. If you suspect illness, please consult your doctor or alternative practitioner

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