Why are Ashwagandha Preparations Safe?
In the control group, the patients had received an antidiabetic drug that had the same effect.
Ashwagandha and Cancer
So far, there have only been animal experiments or in-vitro studies on a possible cancer-inhibiting effect of Ashwagandha. It has been shown that ashwagandha can initiate apoptosis (suicide of the cancer cells) and inhibit cancer cell growth (14, 15, 16, 17, 18, 19, 20).
In a mouse experiment, the active ingredients isolated from Ashwagandha showed a reduction in tumor growth of up to 80 percent in mice with ovarian tumors (16). Spread to other organs could also be reduced.
What to Look For When Buying Ashwagandha
If you want to try Ashwagandha and are looking for a high-quality product, make sure to buy organic products to avoid possible pesticide pollution - both for yourself and the environment.
Ashwagandha is available in the form of the ground root. These are available as loose powder or filled in capsules or compressed into tablets. There are also root extracts. They contain the Ashwagandha-typical active ingredients in high concentration and are therefore often more effective than the powder.
At least for the extracts, the withanolide content should be given in percent - ideally at least 5 percent. Sometimes the specific amount of withanolide is also given, which should be around 8 mg per daily dose for extracts. If the salary is not specified, ask the manufacturer / dealer before buying.
In the case of powders, the specific active ingredient contents are generally not specified, as these - in comparison to extracts - are not standardized and the active ingredient quantities can fluctuate from batch to batch.
Properly dose ashwagandha
Ashwagandha powder is taken 2 to 4 g twice a day and this dose can be increased as needed.
As mentioned above, one takes so much of extracts daily that one can achieve a daily dose of 8 mg withanolides. If this effect is too strong for you, reduce it naturally and only take half of it for the time being.
If you only have mild symptoms, the pure plant powder may be sufficient. If the symptoms are more severe, extracts may make more sense, but they can also lead to an overly strong effect more quickly, which means that you should dose carefully - in consultation with a doctor who is versed in naturopathic medicine - it is better to start with smaller doses and closely watching the body's reactions.
When using Ashwagandha, patience is required, as it can take several weeks to months for an effect to be achieved. Sometimes the effect occurs after just a few days.
How to take Ashwagandha
Ashwagandha extract capsules are taken with plenty of liquid. Ashwagandha powder is best stirred in water or fruit juices. But it can also be added to smoothies or mueslis.
If you take Ashwagandha with a meal, the effect could be less or take longer. Therefore, it is usually recommended to take it an hour before meals or two hours after.
The time of day plays less of a role. Especially with chronic complaints, it is important to ensure that it is taken regularly, around twice a day in the morning and in the evening. In this way, you can count on the adaptogenic (protection against stress) effect during the day and on the sleep-promoting effect at night.
It is also often best to pay attention to your own body's reactions. If you get tired after taking ashwagandha in the morning, only take it in the evening. If taking it in the evening shortly before going to bed is not enough for a restful sleep, then take the preparation a little earlier, possibly in the afternoon.
An extremely enjoyable way to take Ashwagandha is the Ashwagandha sleeping potion:
The Ashwagandha Sleeping Potion: Delicious and effective
For the Ashwagandha drink - also known as an Ayurvedic sleeping drink - you need the Ashwagandha powder, a few spices (turmeric, cardamom, cinnamon, etc.), a pack of oat drink and a sweetener, e.g. B. Yacon Syrup. You can find the recipe here: The Ashwagandha Drink - Ayurvedic sleeping drink
Of course, the Ashwagandha drink is not only suitable for falling asleep better. Overall, it has a relaxing and calming effect and helps you to switch off quickly after a strenuous day.
Possible side effects of ashwagandha
Ashwagandha is considered safe in the recommended quantities and has very few side effects. Occasionally, indigestion in the form of e.g. B. Diarrhea occur. If this is the case, reduce the dose or take a break.
According to studies (on rats), dosages of up to 2000 mg ashwagandha extract per kilogram of body weight should remain without side effects (2) - according to a publication from 2016 in Journal of Ayurveda and Integrative Medicine. However, the extract was only given for four weeks. So far, there are no clear studies on long-term effects.
According to a chapter in LiverTox: Clinical and Research Information on Drug-Induced Liver Injury (updated on May 2, 2019) there has been isolated (reversible) liver damage in the past in people who have taken ashwagandha (2 to 12 weeks after ingestion) (3). However, it is emphasized that in many of these cases it is not exactly known whether the problem originated from ashwagandha or another ingredient, as some of those affected had taken mixed preparations.
Ashwagandha during pregnancy and breastfeeding
As there are no studies (yet) on the use of ashwagandha during pregnancy and breastfeeding, it is recommended that ashwagandha should not be used during these phases of life (4, 5).
Who should be careful with Ashwagandha
Some groups of people should discuss the intake with their doctor in advance. These include Patients with diabetes, high blood pressure, thyroid dysfunction, mental disorders and autoimmune diseases.
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- (1) Singh N et al, An Overview on Ashwagandha: A Rasayana (Rejuvenator) of Ayurveda, African Journal of Traditional, Complementary and Alternative Medicines, 2011; 8 (5 Suppl): 208-213.
- (2) Patel SB et al, Safety assessment of Withania somnifera extract standardized for Withaferin A: Acute and sub-acute toxicity study, Journal of Ayurveda and Integrative Medicine, 2016 Mar; 7 (1): 30-37.
- (3) Ashwagandha, LiverTox: Clinical and Research Information on Drug-Induced Liver Injury, May 2, 2019
- (4) Mensah A, Ashwagandha Dangers: This Herbal Remedy may have Repercussions, Mensah Medical, July 16, 2016
- (5) Withania, Drugs and Lactation Database, March 17, 2021.
- (6) Mishra LC et al, Scientific Basis for the Therapeutic Use of Withania Somnifera (Ashwagandha): A Review, Alternative Medicine Review, 5 (4), 334-46 Aug 2000
- (7) Mirjalili MH et al, Steroidal lactones from Withania somnifera, an ancient plant for novel medicine., Molecules, 2009 Jul 3; 14 (7): 2373-93
- (8) Visavadiya NP et al, Hypocholesteremic and Antioxidant Effects of Withania Somnifera (Dunal) in Hypercholesteremic Rats, Phytomedicine, 14 (2-3), 136-42 Feb 2007
- (9) Raut AA et al, Exploratory study to evaluate tolerability, safety, and activity of Ashwagandha (Withania somnifera) in healthy volunteers., Journal of Ayurveda and Integrative Medicine, 2012 Jul; 3 (3): 111-4.
- (10) Agnihotri AP et al, Effects of Withania somnifera in patients of schizophrenia: A randomized, double blind, placebo controlled pilot trial study, Indian Journal of Pharmacology, 2013 Jul-Aug; 45 (4): 417-418.,
- (11) Andallu B and Radhika B., Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root., Indian Journal of Experimental Biology, 2000 Jun; 38 (6): 607-9.
- (12) Sandhu JS et al, Effects of Withania somnifera (Ashwagandha) and Terminalia arjuna (Arjuna) on physical performance and cardiorespiratory endurance in healthy young adults, International Journal of Ayurveda Research, 2010 Jul-Sep; 1 (3): 144-149.
- (13) Wankhede S et al, Examining the Effect of Withania Somnifera Supplementation on Muscle Strength and Recovery: A Randomized Controlled Trial, Journal of the International Society of Sports Nutrition, 12, 43 2015 Nov 25
- (14) Vyas AR and Singh SV., Molecular targets and mechanisms of cancer prevention and treatment by withaferin a, a naturally occurring steroidal lactone., The AAPS Journal, 2014 Jan; 16 (1): 1-10
- (15) Nishikawa Y et al, Withaferin A Induces Cell Death Selectively in Androgen-Independent Prostate Cancer Cells but Not in Normal Fibroblast Cells., PLoS One, 2015 Jul 31; 10 (7): e0134137
- (16) Kakar SS et al, Withaferin A Alone and in Combination with Cisplatin Suppresses Growth and Metastasis of Ovarian Cancer by Targeting Putative Cancer Stem Cells, PLoS One, 2014; 9 (9): e107596.
- (17) Khazal KF et al, Effect of Withania somnifera Root Extract on Spontaneous Estrogen Receptor-Negative Mammary Cancer in MMTV / Neu Mice, Anticancer Research, 2014 Nov; 34 (11): 6327-6332.
- (18) Senthilnathan P et al, Stabilization of membrane bound enzyme profiles and lipid peroxidation by Withania somnifera along with paclitaxel on benzo (a) pyrene induced experimental lung cancer., Molecular and Cellular Biochemistry, 2006 Nov; 292 (1-2): 13-
- (19) Muralikrishnan G et al, Immunomodulatory effects of Withania somnifera on azoxymethane induced experimental colon cancer in mice., Immunological Investigations, 2010; 39 (7): 688-98
- (20) Chang E et al, AshwaMAX and Withaferin A inhibits gliomas in cellular and murine orthotopic models, Journal of Neuro-Oncology, 2016 Jan; 126 (2): 253-64.
- (21) Bhattacharya SK et al, Anxiolytic-antidepressant Activity of Withania Somnifera Glycowithanolides: An Experimental Study, Phytomedicine, 7 (6), 463-9 Dec 2000
- (22) Andrade C et al, A double-blind, placebo-controlled evaluation of the anxiolytic efficacy of an ethanolic extract of withania somnifera., Indian Journal of Psychiatry, 2000 Jul; 42 (3): 295-301.
- (23) Auddy B et al, A Standardized Withania Somnifera Extract Significantly Reduces Stress-Related Parameters in Chronically Stressed Humans: A Double-blind, Randomized, Placebo-Controlled Study, JANA Vol. 11 No. 1 2008
- (24) Cooley K et al, Naturopathic care for anxiety: a randomized controlled trial ISRCTN78958974., PLoS One, 2009 Aug 31; 4 (8): e6628.
- (25) Mahdi AA et al, Withania somnifera Improves Semen Quality in Stress-Related Male Fertility., Evidence-Based Complementary and Alternative Medicine, 2009 Sep 29.
- (26) Chandrasekhar K et al, A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults., Indian Journal of Psychological Medicine , 2012 Jul; 34 (3): 255-62
- (27) Chengappa KN et al, Randomized placebo-controlled adjunctive study of an extract of withania somnifera for cognitive dysfunction in bipolar disorder., The Journal of Clinical Psychiatry, 2013 Nov; 74 (11): 1076-83.
- (28) Sud Khyati S and Thaker Anup B, A randomized double blind placebo controlled study of Ashwagandha on generalized anxiety disorder, International Ayurvedic Medical Journal, Volume 1; Issue 5; Sept - Oct 2013
- (29) Candelario M et al, Direct evidence for GABAergic activity of Withania somnifera on mammalian ionotropic GABAA and GABAρ receptors., Journal of Ethnopharmacology, 2015 Aug 2; 171: 264-72
- (30) Chengappa KNR et al, Adjunctive Use of a Standardized Extract of Withania somnifera (Ashwagandha) to Treat Symptom Exacerbation in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Study., The Journal of Clinical Psychiatry, 2018 Jul 10; 79 (5)
- (31) Ahmad MK et al, Withania Somnifera Improves Semen Quality by Regulating Reproductive Hormone Levels and Oxidative Stress in Seminal Plasma of Infertile Males, Fertility and Sterility, 94 (3), 989-96 Aug 2010
- (32) Gupta A et al, Efficacy of Withania Somnifera on Seminal Plasma Metabolites of Infertile Males: A Proton NMR Study at 800 MHz, Journal of Ethnopharmacology, 149 (1), 208-14 2013 Aug 26,
- (33) Ambiye VR et al, Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males: A Pilot Study, Evidence-Based Complementary and Alteranative Medicine, 2013; 2013: 571420.
- (34) Lopresti AL et al, A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha (Withania somnifera) in Aging, Overweight Males., American Journal of Men's Health, 2019 Mar-Apr ; 13 (2): 1557988319835985.
- (35) Dongre S et al, Efficacy and Safety of Ashwagandha (Withania Somnifera) Root Extract in Improving Sexual Function in Women: A Pilot Study, BioMed Research International, 2015
- (36) Mikolai J et al, In Vivo Effects of Ashwagandha (Withania Somnifera) Extract on the Activation of Lymphocytes, Journal of Alternative and Complementary Medicine, 15 (4), 423-30 Apr 2009
- (37) Bhat J et al, In Vivo Enhancement of Natural Killer Cell Activity Through Tea Fortified With Ayurvedic Herbs, Phytotherapy Research, 24 (1), 129-35 Jan 2010,
- (38) Khan MA et al, Effect of Withania Somnifera (Ashwagandha) Root Extract on Amelioration of Oxidative Stress and Autoantibodies Production in Collagen-Induced Arthritic Rats, Journal of Complementary & Integrative Medicine, 12 (2), 117-25 Jun 2015
- (39) Noshahr ZS et al, Protective Effects of Withania Somnifera Root on Inflammatory Markers and Insulin Resistance in Fructose-Fed Rats, Reports of Biochemistry & Molecular Biology, 3 (2), 62-7 Apr 2015
- (40) Orrú A et al, Withania Somnifera (L.) Dunal Root Extract Alleviates Formalin-Induced Nociception in Mice: Involvement of the Opioidergic System, Behavioral Pharmacology, 27 (1), 57-68 Feb 2016
- (41) Kumar G et al, Efficacy & Safety Evaluation of Ayurvedic Treatment (Ashwagandha Powder & Sidh Makardhwaj) in Rheumatoid Arthritis Patients: A Pilot Prospective Study, The Indian Journal of Medical Research, 141 (1), 100-6 Jan 2015
- (42) Ramakanth GS et al, A randomized, double blind placebo controlled study of efficacy and tolerability of Withaina somnifera extracts in knee joint pain., Journal of Ayurveda and Integrative Medicine, 2016 Jul - Sep; 7 (3): 151-157 .
- (43) Baitharu I et al, Withania Somnifera Root Extract Ameliorates Hypobaric Hypoxia Induced Memory Impairment in Rats, Journal of Ethnopharmacology, 145 (2), 431-41 2013 Jan 30
- (44) Manchanda S et al, Aqueous Leaf Extract of Withania Somnifera as a Potential Neuroprotective Agent in Sleep-deprived Rats: A Mechanistic Study, Molecular Neurobiology, 54 (4), 3050-3061 May 2017
- (45) Pingali U et al, Effect of Standardized Aqueous Extract of Withania Somnifera on Tests of Cognitive and Psychomotor Performance in Healthy Human Participants, Pharmacognosy Research, 6 (1), 12-8 Jan 2014
- (46) Choudhary D et al, Efficacy and Safety of Ashwagandha (Withania Somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions, Journal of Dietary Supplements, 14 (6), 599-612 2017 Nov 2
- (47) Gannon JM et al, Subtle Changes in Thyroid Indices During a Placebo-Controlled Study of an Extract of Withania Somnifera in Persons With Bipolar Disorder, Journal of Ayurveda and Integrative Medicine, 5 (4), 241-5 Oct-Dec 2014
- (48) Sharma AK et al, Efficacy and Safety of Ashwagandha Root Extract in Subclinical Hypothyroid Patients: A Double-Blind, Randomized Placebo-Controlled Trial, Journal of Alternative and Complementary Medicine, 24 (3), 243-248 Mar 2018
- (49) Pratte, Morgan A., et al. "An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera)." The Journal of Alternative and Complementary Medicine 20.12 (2014): 901-908.
- (50) Kaushik, Mahesh K., et al. "Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction." PloS one 12.2 (2017).
- (51) Deshpande, Abhijit, Nushafreen Irani, and Rathna Balakrishnan. "Study protocol and rationale for a prospective, randomized, double-blind, placebo-controlled study to evaluate the effects of Ashwagandha (Withania somnifera) extract on nonrestorative sleep." Medicine 97.26 (2018).
- (52) Panda S, Kar A, Changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice, J Pharm Pharmacol. 1998 Sep; 50 (9): 1065-8.
- (53) Salve J, Pate S, Debnath K, Langade D, Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study, Cureus. 2019 Dec 25; 11 (12): e6466. doi: 10.7759 / cureus.6466.
- (54) Langade D et al., Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study, Cureus. 2019 Sep 28; 11 (9): e5797. doi: 10.7759 / cureus.5797.
- (55) Kelgane SB et al., Efficacy and Tolerability of Ashwagandha Root Extract in the Elderly for Improvement of General Well-being and Sleep: A Prospective, Randomized, Double-blind, Placebo-controlled Study, Cureus. 2020 Feb 23; 12 (2): e7083. doi: 10.7759 / cureus.7083.
Studies / sources marked in italics are not used in the text and are only listed for the sake of completeness.
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This information is passed to the best of my knowledge and belief. They are intended exclusively for those interested and for further training and are in no way to be understood as diagnostic or therapeutic instructions. We do not assume any liability for damages of any kind that arise directly or indirectly from the use of the information. If you suspect illness, please consult your doctor or alternative practitioner
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